MT-II and GHK-Cu

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Both Melanotan II and GHK-Cu are actively studied peptides in dermatology, but for very different reasons.

• Melanotan II is studied for pigmentation, but has a more systemic activity and also affects libido, and brain-related pathways, it remains experimental and unapproved 
• GHK-Cu is studied for healing, skin repair, and anti-aging, with much stronger and longer-standing scientific support.

Here’s a clear, evidence-based breakdown of what each peptide is being researched for.

MT-II (Melanotan II) is a synthetic analog of the naturally occurring Alpha Melanocyte Stimulating Hormone (α-MSH). It is an agonist of the melanocortin receptors (MC1R, MC3R, MC4R and MC5R), and has been widely studied for its effects on melanogenesis (skin pigmentation) and UV protection. Additionally, it has shown promising applications in the field of appetite regulation, libido and sexual function.

Skin pigmentation and tanning

Even with minimal UV exposure, melanin production in the skin is promoted, resulting in darker skin tone.

Photo protection

The increased pigmentation of the skin results in better protection against UV induced skin damage. It works by activating melanocytes to produce eumelanin, which is a protective pigment.

Sexual behaviour and libido

Through activation of Melanocortin receptors, it also acts upon the sexual arousal pathways, resulting in increased sexual desire and erectile function.

Weight management

Because it influences the central nervous system, it is also widely being studied for controlling appetite, satiety, increasing energy expenditure and fat oxidation. It could be useful for weight regulation and metabolic disorders.

Common side effects include nausea, flushing, reduced appetite, fatigue, injection side irritation, spontaneous erection in males. Possible changes in moles on skin.

GHK-Cu is a naturally occurring peptide complex that is composed of 3 amino-acids (Glycine – Histidine-lysine) and copper (II) ions. It is found in human saliva, plasma and urine, and has gained particular interest in the fields of dermatology due to its anti-ageing, skin regeneration and hair growth properties.

The naturally present peptide diminishes with age: average concentration at 20 years is 200 ng/mL, but at 60 this has dropped to 80 ng/mL.

Anti-ageing

It enhances skin elasticity and reduces wrinkles, as was shown in dermal studies. Especially effective for UV damage repair. It also appears to influence genes that are linked to repair, aging and cell survival, which makes it a peptide of interest to support longevity.

Hair growth

Lab research has found it boosts hair follicle regeneration, proliferation and growth phase extension in models of androgenic alopecia.

Tissue regeneration and wound repair

Through its actions of angiogenesis (formation of new blood vessels), inflammatory response suppression and stimulating epidermal thickness, it helps to accelerate wound healing. Because it also stimulates collagen production and tissue remodelling, it had gained much interest in treatment of skin wounds and surgical recovery.

Redness or warmth around injections site, light swelling, short term irritation can occur, mostly due to improper handling.